|
KMID : 1011420130180020093
|
|
Journal of Korean Ophthalmic Optics Society
2013 Volume.18 No. 2 p.93 ~ p.99
|
|
|
Development of Paper-based Microfluidic Device for Dry Eye Test
|
|
Seo Young-Tae
Noh Hye-Ran
|
|
|
Abstract
|
|
|
|
Purpose: The aim of this study was to develop a dry eye test method using a paper based microfluidic device that improves inaccuracy caused by using one of current point-of-care dry eye tests such as Shirmer`s. Methods: Wax printed hydrophilic chromatography papers were dyed with anthocyanin extracts to detect colorimetric display of liquid samples with varying pH. Fluid distribution rates were measured using artificial tears and human tears directly from 32 subjects. Results: With Shirmer`s, fluid distribution rates with small amount of samples (less than 0.5 μl) were not displayed. However, with paper based microfluidic device, fluid imbibition distances over time were clearly showed. Also clinical results of dry eye from newly developed paper based microfluidic device showed correlation with the results from tear break up time tests. Conclusions: The newly developed paper based microfluidic devices were easy to use and exhibited more accurate clinical results than current dry eye point of care tests such as Shirmer`s.
|
|
|
KEYWORD
|
|
|
Dry eye test, Shirmer`s test, Microfluidics, Capillary action
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|